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Inorganic silver antimicrobial


For Cosmetic

For Cosmetic

Possible to maintain the quality of cosmetic without using paraben.

For Water Based Coating

For Water Based Coating

Possible to achieve antimicrobial efficacy at low dosage level.

For ABS resin

For ABS resin

Possible to achieve antimicrobial efficacy at low dosage level.

Following table shows industrial applications example of IONPURE.

Field Application
Daily necessities Chopping board, Disposable gloves, Bowl, Kitchenware, Kitchen knife handle, Duster, Washbowl, Toothbrush, Wrapping film, Canteen, Emergency water tank, Hairbrush, Toilet seat, Cleaner etc.
Electric application Refrigerator, Dish washer, Dish dryer, Mobile phone, Water cleaner, Iron, Gas table, Remote controller etc.
Automobile parts Steering wheel, Shift knob, Switches, Assist grip, Parking break lever etc.
Fiber Socks, Pantyhose, Tights, Insole, Bathing suit, Toilet cobber, Towel, Carpet, Pillow, Sheets etc.
Building materials Wall paper, flooring materials (P tile, Floorings), Mat, Artificial marble (For kitchen counter, Washstand and Bathtub) etc.
Medical Measuring instrument, Hospital floor, Curtain, Stationery, White dress, Gauze mask etc.
Food relatated Conveyor belt, Floor tray etc.
Others Contact lens utility (Lens keeper, Lens holder), Cosmetics, Credit card etc,


IONPURE is a soluble glass containing antimicrobial metal ions

Glass is generally considered as a material with high chemical inertness due to its strong network structure. However, it is possible to lower this chemical inertness by continuously altering its structure especially in water.
On the other hand, glass has another interesting property, which retains metal as ions. Combination of this property and the above technology has enabled to create glass with low chemical inertness, which can also retain anti-microbial metal ions such as silver and copper. With the presence of water or moisture, the glass will release these metal ions gradually to function as anti-microbial material.
it is well known that these ion have antimicrobial effect. For example, silverware and copperware has been known to prevent decay of water and food since the ancient times.


  • Freely design the anti-microbial effect and life span according to using purpose.
  • Adaptable to all kind of resin in various grades.
  • High performance at low concentration.
  • Keep up transparency of resin such as PP, PC, ABS, AS.
  • Adapt every molding and spinning as its heat-resistance is more than 500℃.
  • Keep up high performance after washing and warm water environment.
  • High level of safety.

Anti-Microbial mechanism

With the presence of moisture, IONPURE releases a few Ag ions gradually. Ag ion has an ability to strongly bind to cellular enzyme of microbes and inhibit enzyme activity of cell wall, membrane, and nucleic acids. In a word, as microbes charged with minus on their surface, Ag ions that have plus are drawn toward microbes, and disturb their electric balance. so that microbes are burst their cell wall and extinguished.
Otherwise as Ag ions are taken into microbes, they react and bond to the cellular enzyme microbes. this inhibits enzyme activity and multiplication of microbes, thus extinguishing the microbes.


Anti-microbial effect

IONPURE can apply to the uses for compounding or coating or dipping of resin and fiber.

【A】In case applying IONPURE to injection use
Bacteria used: Escherichia coli
Sample Number of cells Log Log (Blank)
-Log (Samples)
Beginning 24 hours later
PP plate with 0.1%
1×105 <1×102 <2.0 >5.7
Blank 1×105 5×107 7.7 -

Note 1)Test method: in accordance with JIS Z 2801

Bacteria used: Staphylococcus
Sample Number of cells Log Log (Blank)
-Log (Samples)
Beginning 24 hours later
PP plate with 0.1%
1×105 <1×102 <2.0 >4.8
Blank 1×105 6×107 6.8 -
【B】In case applying IONPURE to fiber use
Bacteria used: Staphylococcus
Sample Number of cells Log Log (Blank)-Log (Samples)
Beginning 18 hours later
PP fiber with 0.3% IONPURE 8×105 1×102 2.0 4.6
Blank 8×105 4×106 6.6 -
Sample Number of cells Log Log (Blank)-Log (Samples)
Beginning 18 hours later
PET fiber with 0.5% IONPURE 3×104 <1×102 <2.0 >5.0
Blank 3×104 1×107 7.0 -

Note 1) Bacteria used: Staphylococcus IFO 12732
Note 2)Test method: in accordance with JIS L 1902


Fiber containing Ionpure can keep up anti-microbial effect even after washing.

イオンピュア含有PP 繊維の洗濯劣化試験
Sample PP fiber Number of cells Log Log (Black)
-Log (Samples)
Beginning 18 hours later
IONPURE non washed 3×104 <2×102 <2.3 >4.7
IONPURE 50 wash-cycles 3×104 <2×102 <2.3 >4.7
Blank 3×104 1×107 7.0 -

Note 1) Bacteria used: Staphylococcus aueus IFO 12732
Note 2) Test method: in accordance with JIS L 1902

Result of washing deterioration test for PET fiber with IONPURE
Sample PP fiber Number of cells Log Log (Black)
-Log (Samples)
Beginning 18 hours later
IONPURE non washed 3×104 <2×102 2.3 >5
IONPURE 50 wash-cycles 3×104 <4×102 2.6 4.7
Blank 3×104 2×107 7.3 -


Heat-resistance of IONPURE is more than 500℃. as it is inorganic. It is possible to apply to every molding and spinning. Moreover, it can apply heat-resistant container made from resin.


IONPURE is not discolored by compounding and with age, as it is can control the speed of releasing metal ions which have anti-microbial effect.

Life span of effect

To be enable to design freely it's life span of effect by combining glass composition and metal ions having anti-microbial effect is only IONPURE.

Unsaturated polyester with IONPURE (After accelerated test)
Sample PP fiber Number of cells Log Log (Black)-Log (Samples)
Beginning 24 hours later
Boiled 500 hours 1×105 1×104 4 3
Boiled 1000 hours 1×105 3×104 4.4 2.6
Blank 1×105 1×107 7.0 -

Note 1) Used bacteria: Escherichia coli NBRC 3972
Note 2) Test method: in accordance with JIS Z 2801


In general, adding inorganic material to transparent resin such as PP, PVC, ABS, PS, cause the turbidity. but Ionpure, as it is glass, can keep up the transparency of resin to control its refractive index.

Sample Number of cells Log Log (Blank)-Log (Samples)
Beginning 24 hours later
GP-PS with 0.15% IONPURE 2×105 <1×102 <2.0 >5.0
Blank 2×105 1×107 7.0 -

Note 1)Bacteria used: Escherichia coli NBRC 3972
Note 2)Test method: in accordance with JIS Z 2801

The properties of plastics

IONPURE does not effect the properties of plastics.

Strength test for PC with IONPURE
Strength test Test method Material
Blank PC plate PC plate with
Tensile strength 50mm/min ASTM D-638
At yield point 642 639
At break point 746 662
Bending strength 3mm/min ASTM D-790(kg/cm2) 924 931
Impact strength ASTM D-256(kg・cm/cm2) 82.60 83.86
Heat transforming
temperature load 18.5kg
ASTM D-648 (℃) 132.4 132.8

Safety of IONPURE

IONPURE has acquired various safety data for each grade of the product. Following are examples of safety data.

  • Acute oral toxicity
    There was no case of abnormal reaction or death by single oral administration of 5000mg/kg(2000mg/kg) of IONPURE to mice.
  • Primary skin irritation
    No skin irritation response was observed an albino rabbits during or after the skin irritation test suggested in the OECD Chemical Substance Toxicity Test Guidance.(1981)
  • Mutagenicity
    The mutagenicity test based on the bulletin No.77 of the Labor Ministry of Japan (1st Sep.1989)resulted in no increase in reverse mutation and mutagenicity was confirmed to be negative.
  • Skin sensitization
    The skin sensitization test using maximization method demonstrated no skin sensitization on guinea pigs.
  • Inhibition of colony forming
    In accordance with "Guidelines for Biological Tests of Medical Devices" (No.99), the value was 0.51mg/ml for inhibition of 50% colony forming (IC50).

In addition to above test results, eye irritancy test, photo toxicity test, and repeat insult patch test have been performed for other grades of IONPURE. Also, other products containing IONPURE have exhibited excellent safety data in human patch test and quality assurance test for food containers and appliances based on Food Hygiene Law of Japan.


Registration Status of 'ION PURE' in the USA

'Ion pure' is approved in different kinds of legislation in worldwide.

  • 1.EPA Approved

    Ion pure is FIFRA (The Federal Insecticide, Fungicide, and Rodenticide Act) approved.
    EPA approved Ion pure can be used for applications related to non-food contact, food contact, and drinking water applications. For example, polymer incorporated applications, tupperware, artificial counter top, drinking water filter, and ice machine applications etc. It is prohibited to distribute and market an antimicrobial agent without EPA approvals in the USA.

    Food Contact & Drinking Water
    • ION PURE WPA (73148-1)
    • ION PURE IPL (73148-3)
    Non-Food Contact
    • ION PURE ZAF (73148-2)
    • ION PURE IZA (73148-5)
    • ION PURE ZAF HS (73148-6)
    • ION PURE ZAF MS (73148-7)
    • ION PURE IPI (73148-8)
  • 2.FDA Approved

    Ion pure is FDA (Food and Drug Administration) approved.
    Ion pure can be applied to any polymers used for industrial or food packaging use application.
    Listed applications are, food wrapping applications, tray, bottles, containers used for delivery of food

    • FCN No. 000432 ION PURE IPL
    • FCN No. 000433 ION PURE WPA
    • FCN No. 000476 ION PURE IZA
  • 3.NSF

    Ion pure is listed under NSF (National Sanitation Foundation) approved substance under NSF Standard 51.
    With this registration, Ion pure can be applied in polymeric applications which are used in food contact settings.
    Possible applications are, dish washer, ice machine, refrigerator, kitchen utensils, belt conveyor

    NSF Standard 51

Registration Status of 'ION PURE' in EU

  • 1.BPR (Biocidal Product Regulation) Regulation (EU) 528/2012

    BPR became effective after 1 September 2013. All biocidal products require an authorization before they can be placed on the market. In addition, the active substances contained in the biocidal product must be approved previously. Dossiers of Ion pure have already been submitted in 2007 and 2008, and Ishizuka Glass is directly involved in this evaluation process.
    →BPR evauation is still on going. Additional information will be updated as evaluation goes on.
    Article 95 List: Silver Phosphate Glass
    Active substances which are not listed under Article 95 listing after 1 September 2015 can no longer be marketed in EU.

    Ishizuka is listed under Article 95 list
    Active Substance: Silver Phosphate Glass
    Listed as: Substance & Product Supplier
  • 2. EFSA (European Food Safety Authority)

    Ion pure has received an EFSA opinion concluding this substance can be applied in food contact applications.

    Ion pure grades received an EFSA opinion
    • ION PURE IPL (86432)
    • ION PURE WPA (86432-20)
    • ION PURE ZAF (86432-40)